Tianeptine sulfate dosage reddit I started out with the recommended 12. At other times we enjoy about 6 hours of bliss with 100 mg of sulfate. While Tianeptine sulfate works very well at eliminating anxiety and depression, I worry about the long term consequences and plan to stop its use. Medical professionals have documented numerous adverse reactions in tianeptine users that signal its serious health implications. I had a friend from South Africa who’d use Tianeptine Sulfate to get high as that’s all his South African domestic vendor sold Tianeptine-wise and he’d typically take 500 milligrams of Tianeptine Sulfate. What are the side effects of tianeptine? All at once. In 2023, 391 cases of tianeptine poisoning were reported in the United States. If you’re going to abuse tianeptine in high doses, occasional (one dose every several weeks or months) is fine (low withdrawal risk) Jan 24, 2024 · The US Food and Drug Administration is warning consumers not to purchase or use any tianeptine products, saying it continues to receive reports of severe adverse events, including death, linked to The average Cmax value for Stablon in the table is 464, and the three Cmax values for the CR tianeptine sulfate tablets (multiplied by 1. If affordability allows, tianeptine Sulfate could be a worthwhile option. For more information about tianeptine, click here. It also was advertised as having minimal side effects. I measure out my dose and just lick it up so it took about 20-30 minutes to enter my bloodstream. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in While this offers advantages for tianeptine over the tricyclic antidepressant agents in terms of dose titration, treatment changes and potential drug interactions, its rapid elimination makes adherence to dosage schedules more important. Tapering back down was easy though. [ 67 ] Feb 2, 2024 · Side effects of tianeptine use include: Agitation. I don't find any benefits from splitting the doses. Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) 3. It does NOT dissolve in water. Control Status: Tianeptine is not controlled under the Controlled from what I gather, a recreational dose for t. Analysis of tianeptine use in the United States is limited, with most publications originating from other countries . To prepare, I purchased green bali kratom powder, 3 packages of immodium tabs, and cold & flu medicine all on a friend’s recommendation. With the sulfate I now dose around 60mg in the morning and another 40mg 4 hours later - that way I get a solid 16 hours with less highs and lows out of it. Unlike other antidepressant agents, tianeptine stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT) in rat brain synaptosomes and rat and human platelets, increas … Tianeptine Sulfate, though pricier, offers a smoother tapering process due to its extended effects. 5mg sodium. At that dose (or any starting dose), the body will adapt and quickly achieve homeostasis which naturally leads to upping the dose in order for it to remain effective. Longer come up, peak, residual effects. sulfate? however some sources claim that ~100mg sulfate is enough. [66] In 2022 Tonix Pharmaceuticals received permission from the US FDA to conduct phase II clinical trials on tianeptine hemioxalate extended-release tablets designed for once-daily use. It's pretty common knowledge by now, in r/nootropics, that if you're taking Tianeptine Sodium 12. , then your conversion for Tianeptine Sulfate is ~40mg q. So far I’m trying 20mg to see how it goes and will compare it to 25mg sulfate. I sometimes take more than the suggested dosage, but have no side effects. Since Tianeptine Sodium is dosed at 12. 5mg over the usual sodium dosing in a day. 5mg sodium = 40mg sulfate. Personally, I've had positive experiences with tianeptine from rcd. May 12, 2025 · Recognizing tianeptine’s dangerous side effects. Aug 3, 2019 · Among 83 tianeptine exposures with noted coexposures, the most commonly reported coexposures were to phenibut, ethanol, benzodiazepines, and opioids. Much of the recent literature regarding tianeptine comes from case reports and review articles. (i. Anyways, I find 80mg a day works for me. Sometimes you need a short, strong dose of pain-free energy which, in our case, calls for 40 mg of sodium. Tianeptine came out as Prozac was becoming a sensation, bringing a new era of selective serotonin-reuptake inhibitor drugs, or SSRIs. , underscoring its potential dangers. poison control centers during 2000–2017. Or check it out in the app stores 12. This morning I increased the dose to 20mg in the empty capsule, but still I mistakenly thought 12. it lasts yeah about 1. Tianeptine differs from most antidepressants in that it is not primarily metabolised by the hepatic It seems to have a longer duration all around. 3x regular dose) Tianeptine Sulfate would get you the same peak blood plasma concentration as the Sodium version (~430 ng/ml), however, it would last much longer, with significant levels still in the blood 12 hours later (~204ng/ml). The feeling of a large sulfate does is comparable to a low dose of methadone. These side 75mg/day isn’t a recreational dose, especially sulfate. I feel bad for what I read on here as from an outsider’s perspective, we see US nihilism. but man that 45 minute section where you go from barely feeling it to peak is amazing. However, it can also be found on the Internet as tianeptine sulfate sold as a nootropric. Prefer tramadol or DHC very low dose. Tianeptine sulfate not as effective as tianeptine sodium. bio and found their products effective for tapering purposes. I learned after 12. Basically double reccomended dose, and had intended to max out at 40mgx3 or 60mgx2= 120mg a day to match what I mistakenly thought was the therapeutic dose. If possible, it was taken with, or shortly after the tianeptine sulfate dose. The sulfate is much forgiving in his regard, and single doses of 50-60mg, spread out, shouldn’t lead to rebound anxiety or adddoction/tolerance. Anhedonia. Some of these poisonings occurred the first time people ingested the substance. Most will take it 3x a day. sulfate, so does that equate to 300-400mg of t. The guy who runs nootropicsdepot did the math and apparently 45mg Sulfate =~ 37. Has anyone else experiences Based on the graph of effects, it looks like one daily dose of 41mg (3. Like the other poster said, if I take enough it's like I could not be sad or get upset. Day 1 - last dose at 11:30am We would like to show you a description here but the site won’t allow us. 5mg/3 Stablon doses, it might be a useful and effective drug, but I can't visualize this happening. I'm actually starting to like the feeling more than sodium. Lastly, I believe the equivalent dose of sulfate to sodium is 45mg or something. Am I setting myself up for disaster? We use both tianeptine sodium and sulfate. Just a few rough days here and there. Overdose. It has been the best month in a long long time. I could feel the effects within 40-45 mins after ingestion. Update: 20-30mg seems like an appropriate dose once a day. Tianeptine is used as a prescription drug in some European, Asian, and Latin American countries, but it is not approved as a drug in the United States. Does this mean Tianeptine ethyl ester is a prodrug for Tianeptine sulfate? Is Tianeptine ethyl ester sulfate the same as Ethyl Tianeptine i? Maybe something like therapy, a healthier diet, or trying to do more exercise can help. 25, 138. 5 mg tablet — and because the body clears it quickly, doses were to be taken three times a day. But I didn't experience anything. References. Calls for drug information or identification were excluded. But the article follows up with information about the anxiolytic properties of the drug compared to SSRIs. Hope this helps. 5-25 mg at once, 3x a day) (low withdrawal risk) . I was taking tianeptine sulfate during the 3 days leading up to withdrawal. Depressive symptoms. , reports of severe side effects involving tianeptine are increasing. See full list on azbigmedia. 5mg - 25mg (ie 1-2 Stablon tablets) PRN 0-10 x a week. Increased anxiety. Tianeptine sodium is shorter lasting than tianeptine sulfate. If used at 12. I picked up some Tianeptine sulfate from nootropics depot. This compares to 151 cases in 2020, and only 4 in 2013. Tianeptine sulfate; Tianeptine sodium . I read that: “Tianeptine ethyl ester sulfate is a stable salt of an ester compound which is a precursor to Tianeptine…”, and: “Tianeptine ethyl ester” is also a synthetic intermediate fo Tianeptine. along with other adverse side effects like lethargy, elevated blood pressure and In the U. Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants 1 . At the recommended dosage of around 10-15 mg I noticed immediate antidepressant effects. 75 and 125. I put it in an empty capsule. Don't do that. Would it then follow that: Tianeptine free acid would have a little bit more of a peak, that would then taper off very slowly; Tianeptine sulfate would have a slow and steady effect all the way through; and both versions make it difficult to achieve a level of absorption that could produce a Tianeptine "high" or overdose. Get app Get the Get the Reddit app Scan this QR code to download the app now. d. (Caution advised though, this dose is considered to be higher than the recommended dosage, although imo not recreational yet). i. I figured that taking 2x 25mg sulfate capsules once daily is what is going to provide the desired therapeutic effect. Objectives. consumers ingesting daily doses on the order of 1. If you were to dose 7mg of sulphate every 5 hours 3 times a day, when you wake up the second day your blood tianeptine would be around 3mg, rising to 10mg after your first dose, lowering to 5mg before your second dose, rising to 12mg after and then 6mg before your third dose. Negative affect at high doses. Further research is needed to Oct 20, 2023 · Tianeptine is an over the counter antidepressant that mimics opiates in some ways and can be highly addictive. Both subjects reported that their time between tianeptine sulfate doses (varying 100 -200 mg) immediately lengthened by 15-30%, as the agmatine was clearly increasing the systemic duration and efficacy of May 8, 2025 · Case reports in the medical literature describe U. I had given up on antidepressants but decided to give it a try, I felt a difference within minutes. All the newspaper articles we read are about a dying countr I’d wanted to quit for months, and this forced me. S. Am I setting myself up for disaster? Tianeptine is usually packaged as a sodium salt but can also be found as tianeptine sulfate, a slower-releasing formulation patented by Janssen in 2012. Severe vein damage from injecting. sodium is ~100mg, and is between 3-4 times more potent than t. 200mg sulfate works well for me too. Misuse of tianeptine sodium has been documented, but there’s little scientific evidence of tianeptine sulfate use. This is in addition to tianeptine sulfate I have taken for years. Tianeptine is an unapproved drug in the U. I believe most literature describes up to 100mg/day as still being in the therapeutic range Jan 12, 2024 · Overdosing on tianeptine, particularly in combination with other substances, can be fatal, necessitating emergency intervention like naloxone. To give you an idea of it’s strength, 200 milligrams of Tianeptine Sulfate equals 100 milligrams of Tianeptine Sodium. I believe most literature describes up to 100mg/day as still being in the therapeutic range Tianpetine probably has similar rates with certain side-effects in common SSRIs such as dry mouth and nausea. Maybe it would be slightly prolonged, but it wouldn't just add on top of the initial dose. Jul 14, 2024 · Its recommended dose was small — one 12. Confusion. If you find that you are able to use tianeptine without too much issue, try to follow to the best of your ability the protocol doctors use in countries where the drug is prescribed and don't exceed those doses. idk the dose i take the mystery dose gas station pills lol. 25 to account for molar mass difference to represent a sulfate dose of 15mg) are 186. I know that this dose is currently 12. Downsides unspecified. 5mg t. 5mg, 3x a day as well as tianeptine sulfate 25mg/50mg once a day. Poison control center cases involving tianeptine exposure have increased nationwide, from 11 total cases between Going to chime in here and say that tianeptine is worth trying, if you want to. The sulphate tianeptine is supposed to be longer lasting. The only interesting thing I notice from this form but not sooo much in regular sulfate is a bit more of a stimulant effect, which I am As w/anything start w/the lowest possible dose. then gotta wait a good 6 hrs from last dose to be able to get high again I was curious about the ethyl ester sulfate because it supposedly lasts longer than sulfate and potentially is more potent, but I’m not sure. Tianeptine. CDC used NPDS data to review all tianeptine exposure telephone calls reported by U. I have been taking 40mg 2x a day with good effects. Tianeptine is a novel antidepressant agent, both structurally (modified tricyclic) and in terms of its pharmacodynamic profile. 5 hrs of high. Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or I also have a jar of Tianeptine sulfate (which produces similar nootrotpic\mood boosting effects as the Tianeptine sodium) does anyone have any experience with Tianeptine sulfate at recreational dodges? In order to further explore this drug I definitely want to try it at a higher 'recreational' doses. It’s hard to say exactly as it isn’t always as linear and consistent between people’s personal experiences with Tianeptine. 5mg dose. The other took 2800 mg in four doses throughout the day. PubChem. I tried the sulfate for a couple of weeks and didn't notice much, the sodium maybe provided some small lift after trying it for a month but I was getting more benefit from my MAOI and dropped it. along with other adverse side effects like lethargy, elevated blood pressure and Much of the recent literature regarding tianeptine comes from case reports and review articles. I worked myself up to 700mg for a while. Jan 12, 2024 · But the potential for abuse of tianeptine and the toxicity it causes outweigh all benefits. Sulfate gives me a nice subtle high that lasts all day. I'm going to be trying it for pain relief as soon as I figure out a reputable place to get the sulphate kind w/the May 8, 2025 · Case reports in the medical literature describe U. but yeah i take it once, redosing doesn’t work at all. Review the use of tianeptine sulfate without prescription. Seems the dose is equal to 60 mg Tianeptine Sulfate as well so that is a plus. 5mg x3 sodium = 40mg sulfate. So 50mg Sulfate a day isn't too much Laboratory Information System (NFLIS) Drug database collects scientifically verified data on drug items and cases submitted to and analyzed by federal, state, and local forensic drug laboratories. In 2023, 391 cases of tianeptine poisoning were reported in the U. The whole point of using the sulfate is to get the benefits of tianeptine without the short half life of and high peak plasma levels of the sodium. Tianeptine is a very mild opioid, as well as a tricyclic antidepressant so you have t take large doses to feel the opiate effect, and by that time you get bad side effects from the tricyclic part of the drug. com Jan 6, 2023 · Having said that, I would expect that you’d need to dose somewhere between your typical sodium dose and sulfate dose. Desired effect wears off too quickly; short-acting; need to dose frequently. Dependence Look for “tianeptine,” “tianeptine sodium” or “tianeptine sulfate” listed in the ingredients or supplement Learn more about TIANEPTINE uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain TIANEPTINE. Considering the high co-prevalance of anxiety with depression, tianeptine could prove to be the superior drug for these patients. Several hours later I mixed it in some water to see if that would produce results, still nothing. I am getting up in the morning and enjoying my photography hobby, going for runs, and have much more professional motivation and less desire to waste time/play video games all day. I've read that sodium tianeptine takes about an hr to work & only last around 2-3 hrs total. At this dose my cognitive function did not feel impaired nor did I experience any negative side effects. In your example, I would feel the initial 100mg, wait say 30 mins, then take the other 100mg And I wouldn't feel anything above a standard 100mg dose feeling. e. At higher doses, 50-60 mg, there is noticeable sedation which would definitely impair my ability to drive. as one single dose for the whole day) Having collectively established this general consensus, I think we should start reporting what dosages actually work for us. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in r/Tianeptine A chip A close button. We never re-dose or use tia two days in a row or more than twice a week. Several available studies have been conducted to determine the role of tianeptine as a drug of misuse. I tried tianeptine sodium at 12. May 9, 2025 · "Case reports in the medical literature describe U. 3 to 250 times (50 mg to 10,000 mg) the daily tianeptine dose typically recommended in So I’m conclusion: Tianeptine is fine in normal doses daily (12. I used to take tianeptine sulfate @ 100mg a day 1st thing in the morning on empty stomach. The prescription drug is produced as tianeptine sodium. I've noticed that eating a small to medium sized meal about 4 hours after a sulfate dose brings out the feeling quite a bit. 5 mg, usually 3x a day. All in all I’m a big fan of this form. NFLIS-Drug received over 190 reports of tianeptine since its first report in 2017. ywljszz ldycgn yiesptz jaoif svzf eqo lqoj tmnetp pydnok fci
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